Accelerating Native Mass Spectrometry Workflows with DynaChip X1TM Autosampler Integration
Carter K. Asef, Jon Peraza, Casey E. Vantucci, Suraj Dhungana, and Mason Chilmonczyk Andson Biotech, Atlanta, GA Introduction Native mass spectrometry (MS) is becoming increasingly valuable in modern biotherapeutics development. The study of proteins in their native state provides insights into higher-order structures, non-covalent interactions, and multimeric assemblies which are lost under denaturing conditions. Achieving […]
Automated Online Buffer Exchange for Native MS and CDMS Analysis of RNA Therapeutics
Casey E. Vantucci, Lauren Schmitt, Carter K. Asef, Suraj Dhungana, and Mason Chilmonczyk Andson Biotech, Atlanta, GA Introduction RNA-based therapeutics represent a rapidly expanding class of biotherapeutics, spanning a diverse range of modalities with distinct physicochemical properties and analytical requirements. These range from short, chemically modified oligonucleotides such as antisense oligonucleotides (ASOs), small interfering RNAs […]
Rapid Online Buffer Exchange for Complex Native Biological Analysis
Mass spectrometry (MS) is essential for comprehensive characterization of protein therapeutics during biopharmaceutical development.